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M94A1806.TXT
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1994-10-24
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Document 1806
DOCN M94A1806
TI Predictors of hospitalization in persons with HIV-disease.
DT 9412
AU Woodfall B; Hogg RS; Strathdee SA; Le R; Schechter MT; Montaner JS;
O'Shaughnessy MV; British Columbia Centre for Excellence in HIV/AIDS,
Vancouver,; Canada.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):447 (abstract no. PD0396). Unique
Identifier : AIDSLINE ICA10/94370769
AB OBJECTIVE: To determine demographic and clinical predictors of
in-patient hospitalization, overall and in high (HEH) experienced
hospitals, among men and women in British Columbia (B.C.) with
HIV-disease. METHODS: A population-based province-wide cohort study was
based on the Centre's HIV/AIDS drug program which distributes
HIV-related drugs free of charge to all eligible individuals in the
province with HIV-specific indications. Record linkage was conducted
with Hospital Programs (B.C. Ministry of Health) to obtain all records
of in-patient hospitalizations in 1990-93 for participants who
consented. HEH were defined a priori as the 5 tertiary hospitals with
the highest number of HIV/AIDS discharges. Logistic regression
determined which of gender, age, CD4 count, KS, PCP, and geographic
locality were predictive of the most recent hospitalization, overall and
in HEH. RESULTS: Analysis was restricted to 773 persons (735 men; 38
women); the majority (65.4%) were aged 30-44. A total of 335 persons
(310 men; 25 women) were hospitalized between 1990-93. 3-year rates of
hospitalization for men and women were 422 and 658 per 1,000 (see
figure). Of those hospitalized, the mean number of visits was 2.2 (range
1-13) with 58.5% of these stays being 3 days or less. Most visits (77%)
occurred in HEH. Logistic regression revealed that hospitalization was
independently associated with gender (p = 0.0034), low CD4 counts (p =
0.008), and PCP (p = 0.0001) while hospitalization in a HEH hospital was
associated with low CD4 counts (p = 0.0047) and PCP (p = 0.0001).
Univariate analysis of most recent encounters indicated that
hospitalized men were more likely to have lower CD4 counts (p = 0.015),
to be older (p < 0.001), and AIDS-defining illnesses (p = 0.019)
compared to hospitalized women. CONCLUSIONS: This analysis demonstrates
higher hospitalization rates in HIV+ women than men independent of CD4
count. Hospitalized women were less likely to have an AIDS-defining
illness than hospitalized men. Gender differences likely reflect overall
sex-specific variations in morbidity. TABULAR DATA, SEE ABSTRACT VOLUME.
DE Adult British Columbia Cohort Studies Female
Hospitalization/*STATISTICS & NUMER DATA Human HIV
Infections/IMMUNOLOGY/*THERAPY Leukocyte Count Male T4 Lymphocytes
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).